Pharmaceutical Applications of Hot Melt Extrusion - Fundamental Aspects of Drug-Polymer Interaction and Process Development Workshop

Thursday, January 12, 2012
University of MN, Twin Cities East Bank Campus

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Hot melt extrusion (HME) is gaining attention as a useful technique for enhancing delivery of poorly soluble drugs. During this workshop, leading scientists from both the pharmaceutical industry and academia will discuss both fundamental and practical aspects of HME. Schedule

 

Thursday, January 12, 2012
8:00 am - 2:00 pm
Location: Keller Hall 3-210 (first floor)
University of MN, Twin Cities East Bank Campus

The workshop is presented by the IPRIME Biomaterials and Pharmaceutical Materials (BPM) and Microstructured Polymers (MP) programs. Coordinators: Changquan Calvin Sun and Chris Macosko.

Description
Hot melt extrusion (HME) is gaining attention as a useful technique for enhancing delivery of poorly soluble drugs. During this workshop, leading scientists from both the pharmaceutical industry and academia will discuss both fundamental and practical aspects of HME.

Topics will include thermodynamics of polymer - drug interactions, solid-state characterization of extrudates, common polymers for HME, process development and optimization, mechanical properties of drug-polymer systems. IPRIME members with an interest in delivering poorly soluble drugs, HME formulation and process development, and applied polymer science are encouraged to attend.

To Attend
This workshop is free and open to IPrime member companies, invited guests, and University of Minnesota faculty, students, and staff.

Prospective IPrime members interested in attending an IPrime event as an invited guest should contact Bob Lewis, ph: 612-625-1269.

 

Schedule

Morning
7:45
Continental breakfast and sign-in

8:25
Changquan Calvin Sun
University of Minnesota, Pharmaceutics
Welcome and Overview

8:30 Jim DiNunzio
Hoffmann-La Roche, Inc.
Melt Extrusion: Technology Overview and Applications for Early Stage Formulation Development

9:15
Chris Macosko and Frank Bates
University of Minnesota
Fundamentals of Polymer Additive Miscibility

10:00
Coffee break

10:30
Feng Qian
Bristol-Myers Squibb
An Underinvestigated Risk During Solid Dispersion Development: Drug-Polymer Mixing Uniformity

11:00
Shaukat Ali
BASF Corporation
Polymers for Hot Melt Extrusion Technology

11:30
Lunch break (box lunch provided with registration)

Afternoon

12:30
Peng Wang
University of Rhode Island
Extrusion for Drug Manufacturing - Material and Process Aspects

1:00
Changquan Calvin Sun
University of Minnesota
Mechanical properties of acetaminophen - PVPVA system

1:30
Panel Discussion
Current Challenges and Future Applications of Hot Melt Extrusion

2:00
Adjourn